History And Epidemiology Of The Drug - 1314 Words

History and Epidemiology of the Drug Propofol was originally available in 1986 and has been used as an anesthesia, for â€Å"short sedation in endoscopies and cardioversions, and for long-term sedations in intensive care units and also used for rapid opiate detoxification†(Bonnet, 2012). Propofol is used, unapproved by the FDA, as pain reliever for severe chronic headaches and as a sleep aid for insomnia. The Pharmacology, How does it work in the system Propofol’s actions at multiple receptor subtypes account for its potential for misuse/abuse and its lethality in overdose. Propofol alters ventral striatal dopamine. This alteration explains propofol’s addictive properties. Propofol acts at gamma-amino butyric acid receptors and N-methyl-d-aspartate type glutamatergic receptors. Propofol’s actions on GABA and glutamate neurotransmitters that are critical for influencing level of arousal and consciousness, likely account for its anesthetic properties and lethality in overdose. Propofol rapidly redistributes from the plasma into highly perfused brain tissue, and rapid redistribution into adipose tissue accounts for its short duration of action. Propofol has an extremely narrow therapeutic index related to the small dosing window between euphoria and apnea. Propofol is metabolized in the liver through glucuronidation and is renally excreted. (Monroe,2011) The effects of Propofol can be divided into sections. Propofol has sedative effects based on the dosage. It also hasShow MoreRelatedA Good Health System Successfully Delivers Treatment And Prevent Disease1599 Words   |  7 Pages Epidemiology of Health Sciences Mounika ELP: 500 NATIONAL UNIVERSITY Dr. Cruz September 22, 2014 Abstract A good health system successfully delivers treatment and prevent disease. There is rapid growth in health care service sector. This research describes out of our experience of teaching epidemiology both in public health and health programs. 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